Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?

Table 1 The chromosome instability of peripheral blood lymphocytes in P1, P2, and their parents, after studying by conventional and banding cytogenetic methods

Patient	Age at the time of blood sampling	Culture/ chromosome staining	Totally cells scored	Aberrations frequency (%)
P 1	5 years 6 months	72 h/solid (standard)	147	23 (15.6 ± 3.16)
	6 years 2 months	48 h/solid (standard)	132	32 (24.24 ± 3.73)
	6 years 2 months	48 h/GTG	253	83 (32.81 ± 2.95)
	7 years 10 months	72 h/GTG	306	68 (22.22 ± 2.38)
P 2	1 year 8 months	96 h/GTG	35	14 (40.0 ± 8.28)
	4 years 4 months	72 h/GTG	200	19 (9.5 ± 2.77)
Mother	39 years	72 h/GTG	197	6 (3.05 ± 1.31)
Father	38 years	72 h/solid standard	200	16 (8.0 ± 1.92)
	41 years	72 h/GTG	100	4 (4.0 ± 1.96)

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