Table 1 Results of various FISH probes application with the comet assay

-

Whole DNA damage and repair

Genotoxicity testing or biomonitoring of genotoxic exposure and effect

[1–15]

Gene-specific

DNA damage and repair within the vicinity of the gene of interest

Analysis of damage and repair of genes related with cancer (TP53, KRAS, APC, p53)

[41, 46, 51, 53–58].

Analysis of damage of genes Ret, Ab1 and Trp53 as biomarker of X-radiation exposure in vivo

[59]

Spatial distribution of chromosome-specific DNA sequences

[40]

Chromosome locus-specific (centromere-, telomere- and region-specific)

DNA damage within the vicinity of the locus of interest

Analysis of leukaemia-specific chromosome damage

[61]

Analysis of sensitivity of telomeres toward anticancer drugs

[63–65]

WCP

DNA damage within the chromosome of interest

Distribution of DNA damage in genome

[44, 60]

Genetic alterations in carcinogenesis of the upper aerodigestive tract

[62]

Selected probes

Different genomic regions

Transcription-coupled DNA repair

[48]

Elucidation of comet formation

[44–46, 51, 52]