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Archived Comments for: The hierarchically organized splitting of chromosomal bands for all human chromosomes

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  1. From the proof of concept to the application

    Alain Bernheim, Chromosome condensation and sequence

    30 April 2009

    This superb paper clearly demonstrates a condensation asymetry between R and G bands that are intimely linked to the functionnal structure of the genome. It shows also that chromosome banding and sequence are not mathematicaly linked.
    There is a need to address the exact localization and spliting of tiling probes (BAC or smaller) on human genomes (male and female) to assign each bit of the complete sequence to the metaphasic and interphasic chromosomes in detail. This huge project is technically feasible via a consortium. But will be a scientific mobilisation ?

    Competing interests