Figure 1

The fate of an aneuploid neuron. It seems that there are two most probable ways. Firstly, aneuploid neuron can be integrated into neuronal circuitry. This has the potential to produce disease phenotype (through affecting all the elements of the circuitry via synaptic activity of aneuploid neuron) or this could be a probable mechanism of aging; alternatively, if aneuploidy rates are relatively low, integration of aneuploid neuron into neuronal circuitry is suggested to be a mechanism for neuronal diversity. Secondly, aneuploid neuron can be subjected to neuronal cell death. The latter could be associated with large-scale neuronal cell clearance that has potential to lead to brain diseases or, alternatively, to be an aging mechanism.