Figure 2
From: Unusually stable abnormal karyotype in a highly aggressive melanoma negative for telomerase activity
A GTG-Banding and sub-telomere specific FISH composite representative karyotype of the reported melanoma. Subtelomeric FISH verified structural integrity of most chromosomes, canonical orientation of both translocations, the deletions 6q, 10p, and 11q, as well as the isochromosome i(17q). The depicted partial dual or triple color subtelomeric FISH karyotypes derive from 23 independent pseudodiploid metaphases; each black box represents a single mitotic nucleus (Red = Spectrum Orange, Green = FITC, Purple = Spectrum Aqua ×1000) (A). Dual color interphase FISH for centromeres 7 (yellow), and 17 (green), shows remarkable numerical stability in 200 nuclei (error-bars represent the standard error of the mean) (B).