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Table 4 NIPT results for SCA screening in pregnant women of different age groups

From: Noninvasive prenatal testing for assessing foetal sex chromosome aneuploidy: a retrospective study of 45,773 cases

NIPT results

All cases

AMA cases

Age < 30 years

30 ≤ age ≤ 34 years

35 ≤ age ≤ 39 years

Age > 39 years

TP

FP

PPV

TP

FP

PPV

TP

FP

PPV

TP

FP

PPV

TP

FP

PPV

TP

FP

PPV

45,X

7

49

12.5

5

16

23.81

2

18

10

0

15

0

4

14

22.22

1

2

33.33

47,XXX

15

14

51.72

8

7

53.33

4

4

50

3

3

50

4

5

44.44

4

2

66.67

47,XXY

26

13

66.67

15

4

78.95

4

6

40

7

3

70

10

4

71.43

5

0

100

47,XYY

10

2

83.33

4

2

66.67

3

0

100

3

0

100

4

2

66.67

/

/

/

SCA suspected abnormal

0

7

 

0

2

 

0

2

 

0

3

 

0

2

 

/

/

/

Total

58

85

40.56

32

31

50.79

13

30

30.23

13

24

35.14

22

27

44.9

10

4

71.43

  1. NIPT, noninvasive prenatal testing; SCA, sex chromosome aneuploidy; AMA, advanced maternal age; TP, true positive; FP, false positive; PPV, positive predictive value
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Molecular Cytogenetics

ISSN: 1755-8166