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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Identification of mosaic and segmental aneuploidies by next-generation sequencing in preimplantation genetic screening can improve clinical outcomes compared to array-comparative genomic hybridization

Fig. 2

Examples of inconsistent mosaicism between the two chromosome screening platforms generated by the same amplification products. NGS, next-generation sequencing; aCGH, array-comparative genomic hybridization. a Embryo 4C was identified as mosaic with partial deletion of ch.17 (40% of aneuploidy) using the NGS platform, but the mosaicism was not obvious with the aCGH platform. Embryo 7C was identified as mosaic with both the partial duplication of ch.10p15.3-q11.23 (32% of aneuploidy) and partial deletion of ch.10q21.1-q26.3 (44% of the aneuploidy) using the NGS platform, but the mosaicism was not obvious with the aCGH platform. b Embryo 2C was identified as mosaic with partial deletion of ch.6q14.1-q27 using the NGS platform (30% of aneuploidy), but the segmental chromosomal mosaicism was not detected using the aCGH platform. Embryo 28C was identified as a mosaic with partial duplication of 9q21.11-q34.3 using the NGS platform (41% of aneuploidy), but the segmental chromosomal mosaicism was not detected using the aCGH platform

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Molecular Cytogenetics

ISSN: 1755-8166