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Figure 2 | Molecular Cytogenetics

Figure 2

From: Design and validation of a pericentromeric BAC clone set aimed at improving diagnosis and phenotype prediction of supernumerary marker chromosomes

Figure 2

Combined array-CGH and FISH characterization of SRC(4) of patient 3 (A-C) and SRC(11) of patient 5 (D-F). Upper row: (A) Identification of a heterozygous duplication of 15.4 Mb (chr4:45,754,992–61,126,608, hg19) using array CGH (Agilent 4 × 44K) in patient 3. The BAC probes RP11-178N2 at 4p12 (B) and RP11-91C3 at 4q13.1 (C) produce hybridization signals on both chromosomes 4 and the SRC(4). Bottom row: (D) Identification of a heterozygous duplication of 13.4 Mb (chr11:50,378,743–63,743,029, hg19) using array CGH (Agilent 4 × 44K) in patient 5. The BAC probes RP11-746P9 at 11p11.12 (E) and RP11-872D17 at 11q12 (F) produce hybridization signals on both chromosomes 11 and the SRC(11).

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Molecular Cytogenetics

ISSN: 1755-8166