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Figure 1 | Molecular Cytogenetics

Figure 1

From: Incidence and patterns of ALK FISH abnormalities seen in a large unselected series of lung carcinomas

Figure 1

FISH analysis with the ALK dual-color break-apart probe shows variable rearrangement patterns. A) The FDA approved break-apart FISH probe (Abbott Molecular) at 2p23 to detect ALK rearrangements. The 5′ end of the ALK gene is labeled with SpectrumGreen and the 3′ end of the ALK gene is labeled with SpectrumOrange. B) Samples had 1 to 3 split signals. C) Deletion of the green 5′ end of the ALK signal. D) Coexistence of polysomy, split signal, and deletion of the 5′ end of the ALK signal. E) Malignant cells in one patient with adenocarcinoma showing deletion of the 5′ end of the ALK signal and amplification of the 3′ end signals. F) Two patients showed a deletion of the orange 3′ signal and considered negative for an ALK rearrangement.

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Molecular Cytogenetics

ISSN: 1755-8166