GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

Table 2 Molecular neurocytogenetic data on accelerated aging diseases

Disease	Neurocytogenetic findings	CIN	GIN	References
Down syndrome	Presumably 100% (?) of trisomy 21	NS*	NS*	[37, 42, 43]
Alzheimer's diseases (AD)	Chromosome 21-specific aneuploidy confined to degenerated brain areas	+	?	[14]
AD model (transfected human cells with presenelin 1 mutations)	Acquired chromosome missegregation causing aneuploidy	+	+	[46]
Ataxia telangiectasia	Aneuploidy; chromosome breakage producing additional rearranged chromosomes (partial aneuploidy) confined to the degenerated cerebellum	+	+	[14, 20]

ISSN: 1755-8166