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Table 1 Proportion of T21 cell nuclei in foetal ovaries identified by two chromosome 21-specific probes

From: On the origin of trisomy 21 Down syndrome

  

T21 cells (%)

 

Case No/Id

Gest. Age (wks)

Meiotic prophase germ cells

Pre-meiotic germ and stroma cells

Total (%)

1/C14

17

8/1287 (0.62)

6/637 (0.94)

14/1924 (0.68)

2/C19

18

4/753 (0.53)

2/311 (0.64)

6/1064 (0.56)

3/C17

19

9/1221 (0.74)

7/603 (1.16)

16/1824 (0.88)

4/C11

19

3/392 (0.77)

2/575 (0.35)

5/967 (0.52)

5/F8799

13

  

6/1578 (0.77)

6/1C

15

  

2/1048 (0.20)

7/2D

15

  

6/2029 (0.30)

8/3D

22

  

13/2200 (0.59)

Average

 

24/3653 (0.66)

17/2126 (0.80)

68/12634 (0.54)

  1. Note: In cases 1–4 the proportion of germ cells entering meiotic prophase was pre-identified by the meiosis-specific protein STAG3 before the FISH analysis of chromosome 21 copy numbers.