False-positives and false-negatives in non-invasive prenatal testing (NIPT): what can we learn from a meta-analyses on > 750,000 tests?

Table 2 Data from Table 1 is translated into percentages: false-positive and false-negative test results are expressed with respect to all cases tested by NIPT and with respect to all cases having a positive test result after NIPT

with respect to all NIPT tests Table 1 of corresp. tested cases [%]				with respect to Table 1 of corresp. tested cases [%]
Indication	NIPT positives	False positive	False negative	False positive	False negative
a
all	1.858	1.211	0.0079	47.17	0.65
b
T13	0.101	0.048	0.0020	44.25	1.89
T18	0.228	0.041	0.0046	18.52	2.07
T21	0.796	0.077	0.0046	9.79	0.59
SCAs	0.448	0.248	0.0004	55.45	0.08
RATs	0.244	0.206	0.0000	84.50	0.00

ISSN: 1755-8166