Table 5 Summary of the findings of PPVs in different types of aneuploides
Reports | Country | NIPT cases | NIPT positive cases/Validated(%) | PPV | |||||
|---|---|---|---|---|---|---|---|---|---|
T21 | T18 | T13 | SCAs | RCAs | CNVs | ||||
Zhang [8] | China | 146,958 | 1578/1055 (66.9) | 92.2 | 76.6 | 32.8 | – | – | – |
Xue [9] | China | 57,204 | 856/671 (78.4) | 80.4 | 65.3 | 19.5 | 26.8 | – | – |
Chen [10] | China | 42,910 | 534/403 (75.5) | 79.2 | 54.8 | 13.8 | 33.0 | 9.4 | 29.0 |
Liang [13] | China | 94,085 | 965/965 (100) | 94.5 | 82.1 | 46.2 | 46.7 | 28.6 | 40.8 |
Liu [14] | China | 42,924 | 281/281 (100) | 78.5 | 63.0 | 10.0 | 47.2 | – | – |
Luo [15] | China | 40,311 | 468/398 (85.0) | 84 | 48.2 | 14.3 | 34.9 | 9.3 | – |
Xu [16] | China | 31,515 | 434/307 (70.7) | 84.1 | 69.4 | 46.7 | 42.7 | – | – |
Lu [17] | China | 36,913 | 371/277 (61.2) | 84.7 | 58.7 | 41.9 | 33.3 | – | – |
Xu [18] | China | 44,578 | 773/374 (48.4) | 96.0 | 75.5 | 20.0 | – | – | – |
Wang [19] | China | 39,002 | 473/338(71.5) | 88.9 | 53.3 | 20 | 40.2 | 7.3 | 49.0 |
Shi [20] | China | 36,970 | 237/171(72.2) | 81.3 | 47.6 | 17.6 | 56.5 | – | 50.0 |
Fiorentino [21] | Italy | 12,078 | 196/169 (86.2) | 98.9 | 93.8 | 92.3 | 75.0 | 58.8 | – |
Samura [22] | Japan | 30,613 | 554/462 (83.4) | 96.5 | 82.8 | 63.6 | – | – | – |
Guy [23] | USA | 69,794 | 1359/478 (35.2) | 98.1 | 88.2 | 59.3 | 69.0 | – | – |
van der Meij [24] | Netherlands | 73,239 | 343/303 (88.3) | 96 | 98 | 53 | – | 6 | – |
Garshasbi [25] | Iran | 11,223 | 180/170 (94.4) | 95.7 | 92.3 | 87.5 | 70.0 | – | – |
La Verde [26] | Italy | 36,456 | 489/472 (96.5) | 99.2 | 91.2 | 84.4 | 86.7 | – | – |
Soster [27] | USA | 53,099 | 2687/1569 (58.4) | 96.3 | 94.2 | 76.0 | – | 22.4 | 72.6 |