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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: 21q22 amplification detection in three patients with acute myeloid leukemia: cytogenomic profiling and literature review

Fig. 2

Focused chromosomal microarray analysis of 21q22 amplification observed in Patient 1. B-allele frequency and Log R ratio copy number plot of chromosome 21 demonstrate multiple regions of various copy number gains. One breakpoint lies within RUNX1, with high-copy-number gain (~ 3 to 6 copies) of the 5′ region of the gene containing exons 1–6 and low-copy-number gain of exons 7–9 (~ 3 copies)

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Molecular Cytogenetics

ISSN: 1755-8166