Skip to main content
Fig. 1 | Molecular Cytogenetics

Fig. 1

From: 21q22 amplification detection in three patients with acute myeloid leukemia: cytogenomic profiling and literature review

Fig. 1

Representative karyotypes and FISH findings of patients with 21q22 amplification. Patient 1: a karyotype, b interphase FISH showing 5–10 copies of RUNX1 and c metaphase FISH, with RUNX1 localized to hsr(21), chromosome 14, and a marker chromosome. Patient 2: d karyotype, e interphase FISH showing 4–15 copies of RUNX1 and f metaphase FISH with RUNX1 localized to Yp, 5q, 9q, and 22p for this metaphase. Patient 3: g karyotype and hi interphase FISH, showing 10 copies of RUNX1. Arrows denote structural aberrations and circle with slash denote loss of chromosome. Mar = marker chromosome, r = ring chromosome. Dual-colored RUNX1(green)/RUNX1T1(red) probe with nuclei visualized using DAPI (blue)

Back to article page