Fig. 2

FISH analysis of the proband. A mixed probes of p + q sub-telomeres of chromosome 6 (as shown as green and red)and q sub-telomeres of chromosome 13(as shown as orange) showed that the end of the long arm of chromosome 6 was shifted to chromosome 11. B mixed probes of p+q sub-telomeres of chromosome 11 (as shown as green and red), centromeric and p sub-telomere of chromosome 18(as shown as cyan and orange) showed that one of the short arms of chromosome 11 was shifted to chromosome 6, and A+B proved that the long arm of chromosome 6 and the short arm of chromosome 11 were interchanged, as “ish t(6;11)(q27−,p15+ ;p15−,q27+)”, C mixed probes of chromosome 12 p+q terminal (as shown as green and red) and 18p terminal and sub-telomere (as shown as orange and cyan) showed that no abnormalities at the end of the long arm of chromosome 18, D+E proved that one of the long arm of chromosome 16 shifted to the end of the short arm of chromosome 18, as “ish t(16;18)(q24−,p11. 3+ ; p11.3-,q24+)”