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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: The frequent and clinically benign anomalies of chromosomes 7 and 20 in Shwachman-diamond syndrome may be subject to further clonal variations

Fig. 1

Profiles of a-CGH of patient 10 in the BM samples drawn in 2009, showing the i(7)(q10), and in 2017 also showing a deletion of the telomeric region of the short arm (a), which is more appreciable in an enhanced image (b). Double color FISH with the probes indicated in the figure (one located in the short arm, the other in the long arm) shows that two different abnormal clones are present: one with the i(7)(q10) (nucleus with three green and two red signals) (d), one without the i(7)(q10) and with the deletion as demonstrated by the mitosis with one normal chromosome 7 and a deleted one, with only the green signal (c), and by the nucleus with two green and one red signal (e)

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Molecular Cytogenetics

ISSN: 1755-8166