Table 1 Prenatal diagnosis results of fourteen T16 cases predicted by NIPT
From: Outcomes of pregnancies with trisomy 16 mosaicism detected by NIPT: a series of case reports
Case | Age | Gestational week at NIPT | NIPT Z score | NIPT result | Prenatal diagnosis | |
|---|---|---|---|---|---|---|
karyotype | CMA | |||||
1 | 43 | 13 + | 11.345 | T16 | mos47,XN, + mar[8]/46,XN[14] | arr[hg19]4q34.3(178130290–179860825)*3 16p11.2q11.2(30995273–46786489)*3 |
2 | 35 | 18 | 17.824 | T16 | mos47,XN, + 16(4)/46,XN(17) | arr(16) × 2–3 |
3 | 32 | 18 + | 31.503 | T16 | mos47,XN, + 16(1)/46,XN(19) | arr(16) × 2–3 |
4 | 28 | 25 | 8.629 | T16 | mos47,XN, + 16(1)/46,XN(80) | arr(16) × 2–2.3 |
5 | 36 | 17 + | 9.317 | T16 | / | LOH in 16p13.3-p12.3 and 16q23.3-q24.3 |
6 | 23 | 16 | 17.542 | T16 | 46,XN | arr(1–22) × 2 |
7 | 29 | 21 + | 7.791 | T16 | 46,XN | arr(1–22) × 2 |
8 | 34 | 13 | 13.304 | T16 | / | arr(1–22) × 2 |
9 | 27 | 19 + | 7.874 | T16 | 46,XN | / |
10 | 33 | 18 + | 22.812 | T16 | 46,XN | arr(1–22) × 2 |
11 | 31 | 13 | 22.295 | T16 | / | arr(1–22) × 2 |
12 | 39 | 17 | 9.33 | T16 mosaicism | 46,XN | / |
13 | 30 | 15 | 15.14 | T16 | / | arr(1–22) × 2 |
14 | 26 | 18 | 7.98 | T16 mosaicism | 46,XN | / |