Table 5 Studies reporting on screening for chromosomal abnormalities using cell-free DNA in twin pregnancies
Trial | Chromosomal abnormality | n | T 21 | T 18 | T 13 | SCA | Micro deletion | Micro duplication | Population | False positive (n) | Sensitivity for T21 (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Tan et al. [4] | T21 | 565 | 4 | – | – | – | – | – | Mixture | 0 | 100 |
Fosler et al. [11] | T21, T18 | 487 | 6 | 0 | – | – | – | – | Mixture | 1 | 100 |
Le Conte et al. [12] | T21, T18 | 492 | 3 | 1 | – | – | – | – | Mixture | 1 | 100 |
Yang et al. [13] | T21, T18, T7, 47,XXX | 432 | 4 | 1 | – | 0 | – | – | Mixture | 2 | 100 |
Yu et al. [14] | T21, T18, T13 | 1157 | 16 | 4 | 1 | – | – | – | Mixture | 0 | 100 |
He et al. [15] | T21 | 141 | 1 | – | – | – | – | – | Mixture | 0 | 100 |
Motevasselian et al. [16] | T21, T18, T13 | 356 | 2 | 2 | 1 | – | – | – | High risk | 0 | 100 |
Khalil et al. [17] | T21, T18, T13 | 958 | 13 | 1 | 1 | – | – | – | Mixture | 1 | 100 |
Our study | T21, T18, 45,X, 47,XXX, 47,XXY, Microdeletion, Microduplication | 1048 | 1 | 0 | – | 0 | 1 | 0 | Mixture | 11 | 100 |