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Table 3 Detailed information on the thirteen twin pregnancies with NIPT-positive results

From: Performance of non-invasive prenatal testing for foetal chromosomal abnormalities in 1048 twin pregnancies

Case

Maternal age (years)

Gestational age (weeks)

Placentation

Conception

NIPT result

Karyotyping

Clinical outcome

1

36

13 + 6

DCDA

NP

T21 high risk

N/T21

Reduction

2

30

17 + 0

DCDA

NP

T21 high risk

N/N

Natural birth

3

29

17 + 1

MCDA

NP

T18 high risk

N/N

Natural birth

4

26

18 + 4

DCDA

NP

Monosomy X

N/N

Natural birth

5

30

17 + 3

DCDA

NP

Monosomy X

N/N

Natural birth

6

26

18 + 4

DCDA

NP

Monosomy X

N/N

Caesarean

7

39

21 + 4

DCDA

NP

Monosomy X

N/N

Caesarean

8

32

16 + 5

DCDA

ART

Monosomy X

N/N

Caesarean

9

26

17 + 6

DCDA

NP

47,XXX

N/N

Natural birth

10

28

18 + 0

DCDA

NP

47,XXY

N/N

Caesarean

11

39

15 + 1

DCDA

NP

del (15) (q11.2q13.1), 6.13 Mb

N/Microdeletion

Reduction

12

29

17 + 2

DCDA

NP

dup (13) (q31.1q31.1), 2.37 Mb

N/N

Caesarean

13

29

14 + 4

DCDA

ART

dup (16) (p12.3p11.2), 16.38 Mb

N/N

Caesarean

  1. NP, natural pregnancy; ART, artificial reproductive technology; N, normal