Fig. 2From: Prenatal diagnosis of 7 cases with uniparental disomy by utilization of single nucleotide polymorphism arraySNP array results and multiple ultrasonic malformations of three cases involved imprinted chromosome 14 and 15. (a1) SNP array revealed that case 3 arose by monosomy rescue with iso-UPD (14). (a2–a5) The multiple ultrasound malformations observed for case 3 included peritoneal effusion, omphalocele, ventricular septal defect, and small gastric vesicle. (b1) SNP array revealed that case 5 arose by trisomy rescue with mixed hetero/iso- UPD (15) from meiosis I non-disjunction error. (b2–b7) The multiple ultrasound malformations observed for case 5 included scalp edema, chest wall edema, abdominal wall edema, bilateral pleural effusion, ascites, and bilateral kidney edema. (c1) SNP array revealed that case 6 arose by trisomy rescue with mixed hetero/iso-UPD (15) from meiosis II nondisjunction error. (d1) The copy number ratio of the 15q11 region was 1 for two cases of UPD (15). (d2) Methylation ratio of the imprinted allele of chromosome 15q11 after digestion was 1 for two cases of UPD(15)Back to article page