Table 4 Results of studies indicating the efficacy of NIPT in twin pregnancies. All the studies used massively parallel sequencing. (NA: not assessed; DC: dichorionic, MC: monochorionic)
From: Non-invasive prenatal test to screen common trisomies in twin pregnancies
Authors | Number of pregnancies | Chorionicity (DC/ MC) | Conception (spontaneous/ART) | BMI | Maternal age (years) | Gestational age at sampling | Fetal fraction (%) | Sensitivity for trisomy 21 (%) | False positive (number) |
|---|---|---|---|---|---|---|---|---|---|
Gil et al. [9] | 68 | 52/ 16 | 22/ 46 | NA | 37.2 | 10.6 | 7.4 (median of lower fetal fraction) | 100 | 0 |
Huang et al. [10] | 189 | 152/ 33 | 70/ 113 | NA | 31 | 19 | NA | 100 | NA |
Gromminger et al. [11] | 38 | 15/ 5 | 23/ 15 | NA | NA | 14.2 | 14.8 | 100 | 0 |
Bevilacqua et al. [12] | 515 | 301/ 67 | 243/ 272 | NA | 36.8 | 13.6 | 8.7 (median of lower fetal fraction) | 91.6 | 0 |
Tan et al. [3] | 565 | 544/ 18 | 0/ 565 | NA | 31 | 12 | 8.9 | 100 | 0 |
Sarno et al. [13] | 438 | 373/ 65 | 192/ 246 | 23.5 | 37.3 | 11.7 | 8 (median of lower fetal fraction) | 100 | 1 |
Fosler et al. [14] | 487 | NA | NA | NA | 35.5 | 16.6 | 16.1 | 100 | 1 |
Du et al. [15] | 92 | 53/ 39 | 52/ 40 | NA | 30.5 | 17.9 | 20.65 | 100 | 0 |
Le Conte et al. [16] | 492 | 387/ 101 | 301/ 184 | 22.9 | 37 | 16.3 | 13.4 | 100 | 1 |
Yang et al. [5] | 432 | 337/ 95 | 93/ 235 | NA | NA | NA | NA | 100 | 2 |
Present study | 500 (complete follow-up for 356 cases) | 424/ 76 | 317/ 183 | 27.846 | 34.5 | 15.6 | 10.5 | 100 | 1 |