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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Chromoanagenesis: a piece of the macroevolution scenario

Fig. 1

Characteristics of the chaotic mutational processes chromothripsis, chromoanasynthesis and chromoplexy, grouped under the term of chromoanagenesis. Chromothripsis refers to the localized shattering and reshuffling of one or a few chromosome segments during a one-step catastrophic event, with the incomplete repair of double-strand breaks (DSBs) through non-homologous end-joining (NHEJ). Chromoanasynthesis arise from the defective replication of a single or a few chromosomes mediated by fork-stalling and template switching (FoSTeS) or microhomology-mediated break-induced replication (MMBIR) processes. Chromoplexy involves a series of chained, complex inter- and intra-chromosome translocations including up to eight chromosomes and presumably occurring simultaneously

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