Fig. 1
From: Chromoanagenesis: a piece of the macroevolution scenario
Characteristics of the chaotic mutational processes chromothripsis, chromoanasynthesis and chromoplexy, grouped under the term of chromoanagenesis. Chromothripsis refers to the localized shattering and reshuffling of one or a few chromosome segments during a one-step catastrophic event, with the incomplete repair of double-strand breaks (DSBs) through non-homologous end-joining (NHEJ). Chromoanasynthesis arise from the defective replication of a single or a few chromosomes mediated by fork-stalling and template switching (FoSTeS) or microhomology-mediated break-induced replication (MMBIR) processes. Chromoplexy involves a series of chained, complex inter- and intra-chromosome translocations including up to eight chromosomes and presumably occurring simultaneously