Table 1 Oncogenes and tumor suppressor genes (TSG), related to human BC [20, 21] and their involvement in gains or loss of copy numbers in JC cell line
From: Cytogenomic characteristics of murine breast cancer cell line JC
Oncogenes and TSGs | Gene loci in human | JC |
|---|---|---|
NRAS | 1p13~22 | no CNV |
MSH2 | 2p22 | loss |
RAF1 | 3p25 | no CNV |
RARβ2 | 3p24 | no CNV |
MLH1 | 3p21 | no CNV |
APC | 5q21 | no CNV |
MYB | 6q22-q23 | loss |
IGFII-R | 6q26 | no CNV |
MYC | 8q24 | gain |
CDKN2A (p16INK4) | 9p21 | no CNV |
PTEN | 10q23 | loss |
HRAS | 11p15.5 | loss |
FGF3 | 11q13 | loss |
CCND1 | 11q13 | loss |
ATM | 11q22 | no CNV |
CDKN1B (p27kip1) | 12p13 | no CNV |
KRAS2 | 12p12.1 | no CNV |
BRCA2 | 13q12 | loss |
Rb1 | 13q14 | no CNV |
CDH1 (E-cadherin) | 16q22 | no CNV |
TP53 (p53) | 17p13 | no CNV |
BRCA1 | 17q21 | no CNV |
ERBB2 | 17q21 | no CNV |
SERPINB5 (maspin) | 18q21 | loss |
STK11 (LKB1) | 19p13 | loss |
SUM of concordance in CNVs of potentially affected regions | 10/25 | |