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Table 3 The U937 karyotype

From: Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

62<2n> ,

X, +X,−Y,

del(1)(q12),

+der(1)t(1;5)(p22;q31.1),

del(2)(p11.2),

+der(2)dup(2)(q24.1q33.1)del(2)(q33.1),

del(3)(q13.33q24),

+psu dic(3;1)(q25.1;p11.1),

der(5)t(1;5)(p22;q23.3),

+der(5)t(5;13)(q11.2;q14.11)del(5)(q11.2q11.2)1,

+der(6)t(2;6)(p13.2;p22.1),

+ 7,

+dup(7)(p15.3p15.1),

+ 8,

der(10)t(10;11)(p12.31;q14.2)t(10;10)(q23.33q25.2)2,

der(11)t(10;11)(p12.31;q14.2),

+der(11)(16pter->16p11.2::11p11.12->11q12::11q24.12->11q24.2::20q11.21->20q11.21::20p12.3->20pter)3,

+ 12,

+ 15,

der(16)t(4;16)(p13;p12.2)del(4)(p14p14)del(4)(p15.1p15.1)del(4)(p15.31p16.1),

+ 18,

+ 19,

der(20)(20pter->20p12.2::15q14->15q25.3::20p11.22->20q11.21::20p11.21->20p11.21:)4

+ 21,

+ 22 [21] /

63,idem,

+der(6)del(6)(p21.31)amp(6)(p21.31)dup(6)(p21.31p12.2),

del(7)(q22.1q34)[37] /

60,idem,

der(7)t(6;7)(q27;q21.12),

− 12,

− 22[13]

  1. The karyotype was compiled from seventy G-banded karyotypes and interpreted with the aid of M-FISH, locus-specific FISH and SNP array data. Bold text indicates breakpoints that were determined from SNP array data. Balanced translocations were detected by M-FISH and refined by M-BAND and/or G-banding but no information on their breakpoints was provided by SNP array data. The breakpoints of the reciprocal t(10;11) are known by the location of the involved genes. A p → q orientation is assumed when no information is available
  2. 1The complex SNP array pattern on proximal 5q (Fig. 4) was resolved by FISH (Table 2). There were two different deletions of 5q11.2 from the der(5)t(5;13). The smaller deletion occurred in 70% of cells and the larger overlapping deletion in 30% of cells (see Fig. 4 and Table 2). It was not determined which clones these derivatives belong to
  3. 2Submicroscopic deletions of chromosome 10 are noted: homozygous deletion at 10q22.2, del(10)(q22.2q22.2) (chromosome unknown), del(10)(q23.33q23.33) and del(10)(q25.2q25.2). The latter two deletions flank the duplication and therefore we assume they are on the der(11)t(10;11)
  4. 3The position given for the 11q24.1-> 11q24.2 segment in the der(11)t(11;16;20) is based on FISH data (Fig. 3b)
  5. 4This derivative has submicroscopic deletions of 15q14->15q21.1, 15q22.2->15q22.2, submicroscopic duplications of 15q21.1->15q21.3, 15q25.1->15q25.2, and duplication and amplification of a subsection of 20p11.21 in the short arm of the derivative (see Figs. 3, 4, Table 1)
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Molecular Cytogenetics

ISSN: 1755-8166