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Table 1 Results of FISH for derivative chromosomes containing chromosome 20 segments

From: Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

1a

Abnormal chromosome

Band

Chr position (GRCh38)

Marker/clone

der(11)t(11;16;20)

der(20)t(15;20)

11 centromere

 

D11Z1

+

–

11q23.3

11:118436490-118525221

KMT2A (MLL)

–

–

11q24.3

11:128311087-128485203

RP11-754N12 (ETS1)

+

–

11q24.3

11:128694094-128812000

FLI1

+

–

16p13.11

16:15703135-15857030

MYH11

+

–

15q14

15:37089671-37297139

RP11-597G23

+a

 

15q21.2

15:51495000-51629079

RP11-607G03

++a

 

15q22.2

15:60041031-60218374

RP11-366L09

(+)b

 

15q25.1

15:80970069-81137763

RP11-775C24

++a

 

20p11.21

20:22409751-22462800

RP11-500O11

–

++++b

20p11.21

20:22756464-22940284

RP11-755M18

–

+++b

20p11.21

20:23530430-23671508

RP11-218C14

–

++b

20:24130923-24332313

RP11-717H21

–

+

20:24568986-24763965

RP11-580L12

–

+

20:25124608-25306738

RP11-156D15

–

+

20:25306022-25435715

RP11-384D7

–

+

20p11.1

20:25925848-26084581

RP11-269F15

–

+

20 centromere

 

D20Z1

–

+

20q11.21

20:31245645-31409837

RP11-602P9

–

+

20:31435456-31585732

RP11-802B20

–

+

20:31483476-31684958

RP11-363M16

(+)

+

20:31592650-31760766

RP11-702M08

+

+

20:31705215-31874074

RP11-243J16

+

+

20:31902727-32053101

RP11-71I02

(+)

+

20:31935170-32131327

RP11-620H13

(+)

+

20:32022592-32204778

RP11-483M19

–

+

20:32385910-32580055

RP11-724J12

–

+

20:33132629-33305883

RP11-49G10

–

+

20q11.22

20:33458641-33609412

RP11-120F10

–

–

20:33747044-33935043

RP11-541L2

–

–

20:34110945-34261427

RP11-642P13

–

–

20q12

20:42201817-42202000

D20S108

–

–

  1. Each + represents a signal intensity equivalent to one copy on the normal chromosome. (+) represents reduced intensity signal. Positions for each BAC are those given in ensembl.org archives converted to GRCh38 co-ordinates. The order of chromosome 15 and 20 elements in the der(20)t(15;20) is derived from FISH and is described in the karyotype (Table 3)
  2. aVery faint signal—the breakpoint is at distal end of this clone
  3. bOne copy of each is present in the long arm of the der(20) and the additional copies are in the short arm
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Molecular Cytogenetics

ISSN: 1755-8166