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Fig. 4 | Molecular Cytogenetics

Fig. 4

From: Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

Fig. 4

SNP array images and interpretation for each chromosome. SNP array results are arranged by chromosome. For each chromosome the output from the Karyostudio software is displayed against the ideogram. Vertical bars aligned to the right of the ideograms define each segment of the chromosome and its location in a normal or abnormal chromosome. The abnormal chromosomes containing each region are identified when possible. Chromosomes derived from the same homologue are represented in bars of the same colour when this could be determined. N.B. inheritance from the same parent cannot be inferred for different chromosomes represented by the same coloured vertical bar. When breakpoints were adjacent to the centromere, presence or absence of the centromere (chromosome 1) is shown by a solid (present) or hollow bar as shown in the key, if tested. a Horizontal line, balanced translocation, b the regions represented by B allele frequencies of 0:0.25:0.75:1 (arrowed) were deleted from the der(5)t(5;13) in approximately 30% of cells, c B allele frequency and approximately 50% mosaicism for this chromosome suggest approximately ten copies of the most highly amplified section (see Results), d This duplicated region was on a chromosome 7 without the 7q deletion (homologue unknown), e Deleted chromosome not identified, f gain of a short sub-telomeric 8p section was on a cytogenetically normal chromosome 8, g one copy only, presumed on the normal 10, h to explain the AAB/ABB pattern here, we have assumed that the der(10) is most likely to contain both homologues, as conversion of the 10qter segment suggests that the duplication was derived by an unbalanced translocation between the two homologues. i Location of this segment unknown, j additions and deletions of 15q assumed most likely to be on the der(20) reflecting its heritage involving breakage and rejoining events, rather than the normal 15 homologue represented in blue, k inverted repeat of the 20p amplified region. For a high resolution version of Fig. 4, see Additional file 1

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