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Fig. 3 | Molecular Cytogenetics

Fig. 3

From: Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability

Fig. 3

Representative metaphase FISH images clarifying the der(11)t(11;16;20) and der(20)(t(15;20) in U937. a A chromosome 11 centromere probe (red) and an MYH11 (16p13) probe (green) shows that the 11 centromere is in the der(11)t(11;16;20) (closed arrow). The open arrow indicates the der(11)t(10;11). A normal 11 and 16 are also present (labelled with red and green respectively). (Texas Red signal from the CBFB part of the CBFβ/MYH11 probe was not visualised with the filters used for this image.) b The BAC probe RP11-754N12 (11q24.3, representing ETS1) (red) and an MYH11 (16p13) probe (green) show that the extra copy of 11q24.3 material is on the der(11)t(11;16;20) (closed arrow). Open arrow, der(10)t(10;11). A normal 11 and 16 are also present (labelled with red and green respectively). c The 20p11.21 BAC probe RP11-500O11 (red) and 15q21.2 BAC probe RP11-607G03 (green) show the patterns of amplification and duplication respectively of these regions on the der(20)t(15;20) (solid arrow). Normal chromosomes 15 and 20 are indicated by open arrows

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Molecular Cytogenetics

ISSN: 1755-8166