TY - JOUR AU - MacKinnon, Ruth N. AU - Peverall, Joanne AU - Campbell, Lynda J. AU - Wall, Meaghan PY - 2020 DA - 2020/12/14 TI - Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability JO - Molecular Cytogenetics SP - 50 VL - 13 IS - 1 AB - The U937 cell line is widely employed as a research tool. It has a complex karyotype. A PICALM-MLLT10 fusion gene formed by the recurrent t(10;11) translocation is present, and the myeloid common deleted region at 20q12 has been lost from its near-triploid karyotype. We carried out a detailed investigation of U937 genome reorganisation including the chromosome 20 rearrangements and other complex rearrangements. SN - 1755-8166 UR - https://doi.org/10.1186/s13039-020-00517-y DO - 10.1186/s13039-020-00517-y ID - MacKinnon2020 ER -