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Table 1 Comparison of ‘translated’ imbalances of murine MM-cellines AB1, AB22 and AC29 with human epitheloid, biphasic and sarcomatoid MM, according to Krismann et al. [22]

From: Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines

CNV detected in cell lines AB1 Epithelial MM Biphasic MM Sarcomatoid MM
del(1)(pter32) ? + (+)
amp(1)(p31q32) + (+)
del(2)(p23p16) +
amp(2)(q12q21.2) (+) +
del(2)(q22q32) ?
del(3)(p22p10) ? +
del(3)(q10q24) ?
amp(3)(q25q26) ? ? +
del(3)(q27qter) ? ?
amp(5)(p15p12) + +
del(5)(p12q15) ? ? +
amp(6)(p22.1q12) (+) (+) (+)
del(6)(q22.3qter) + + +
amp(8)(q11.2q21.2) + (+) +
del(9)(pterqter) + + +
del(10)(p15p12) + + +
del(10)(q23q25) (+) (+) (+)
del(11)(pterp10) ? +
del(11)(p10qter) ? + +
amp(15)(q21.2q24) + + ?
del(18)(p11.2qter) + ? +
amp(20)(pterqter) + (+)
del(21)(q11.1qter) ? ?
del(X)(pterqter) +
Sum for + 11/16 6/19 12/21
Sum for (+) 3/16 3/19 5/21
Sum for + and (+) 14/16 9/19 17/21
CNV detected in cell lines AB22 Epithelial MM Biphasic MM Sarcomatoid MM
del(1)(pter32) + + (+)
amp(1)(p32p10) + +
del(3)(p24p24) + (+)
del(3)(p21.2p14.2) ? ? (+)
amp(3)(p14.2q21) + + +
del(3)(q26qter) ? ?
del(4)(pterq21.1) + + +
amp(5)(p15.3p12) + +
del(5)(q11qter) ? ? (+)
del(6)(q16q25) + + +
amp(7)(pterp22) + + ?
del(7)(p22qter) +
del(8)(p22p12) + + +
amp(8)(q22qter) + (+) +
del(9)(q21.2q22.3) (+) (+) ?
del(10)(pterq23.2) + + +
amp(11)(q11q13.3) ? ?
del(12)(p12.1qter) ? +
del(13)(q13q32) + + +
del(14)(q11qter) + + +
del(18)(pterqter) + (+) +
del(19)(pterp13.3) ? (+) (+)
amp(20)(pterqter) + (+)
del(22)(q11.2q11.2) + + +
del(22)(q13.2qter) + + +
Sum for + 17/20 11/22 15/23
Sum for (+) 1/20 4/22 6/23
Sum for + and (+) 18/20 15/22 21/23
CNV detected in cell lines AC29 Epithelial MM Biphasic MM Sarcomatoid MM
amp(1)(p31 q25) (+)
amp(2)(p23p11.2) +
amp(2)(q33qter) + +
amp(3)(pterq24.3) +
amp(3)(p14.1p13) + + ?
amp(3)(q25q26.2) (+) (+) +
amp(5)(p15.2p13.1) + +
del(5)(q21q32) ? ? (+)
amp(5)(q33qter) ? +
del(6)(q15q16.1) + + +
del(7)(p21p15.1) + + ?
amp(7)(p13p11.1)
del(7)(q21.3q36) + + +
amp(8)(p12p11.1) +
amp(8)(q22.2qter) + (+) +
del(9)(pterq33) + + +
del(13)(q13q14.1) + + +
del(15)(q13q21.1) (+)
del(17)(pterp12) + + (+)
del(17)(q11q23) ?
amp(17)(q24qter) + (+)
amp(19)(p13.2p13.1) ?
amp(20)(q13.2qter) + +
del(X)(p22p11.2) (+)
Sum for + 14/20 8/23 10/22
Sum for (+) 1/20 2/23 5/22
Sum for + and (+) 15/20 10/23 15/22
  1. Only imbalances present in any of the three human MMs are listed
  2. CNV = copy number variation; + = aberration present in the cell line, − absent in the cell line; ? = no clear correlation possible, as it can be + or − in human cases