Table 1 Comparison of ‘translated’ imbalances of murine MM-cellines AB1, AB22 and AC29 with human epitheloid, biphasic and sarcomatoid MM, according to Krismann et al. [22]
From: Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines
CNV detected in cell lines AB1 | Epithelial MM | Biphasic MM | Sarcomatoid MM |
|---|---|---|---|
del(1)(pter32) | ? | + | (+) |
amp(1)(p31q32) | + | − | (+) |
del(2)(p23p16) | + | − | − |
amp(2)(q12q21.2) | (+) | − | + |
del(2)(q22q32) | − | − | ? |
del(3)(p22p10) | ? | − | + |
del(3)(q10q24) | ? | − | − |
amp(3)(q25q26) | ? | ? | + |
del(3)(q27qter) | ? | ? | − |
amp(5)(p15p12) | + | − | + |
del(5)(p12q15) | ? | ? | + |
amp(6)(p22.1q12) | (+) | (+) | (+) |
del(6)(q22.3qter) | + | + | + |
amp(8)(q11.2q21.2) | + | (+) | + |
del(9)(pterqter) | + | + | + |
del(10)(p15p12) | + | + | + |
del(10)(q23q25) | (+) | (+) | (+) |
del(11)(pterp10) | ? | − | + |
del(11)(p10qter) | ? | + | + |
amp(15)(q21.2q24) | + | + | ? |
del(18)(p11.2qter) | + | ? | + |
amp(20)(pterqter) | + | − | (+) |
del(21)(q11.1qter) | − | ? | ? |
del(X)(pterqter) | + | − | − |
Sum for + | 11/16 | 6/19 | 12/21 |
Sum for (+) | 3/16 | 3/19 | 5/21 |
Sum for + and (+) | 14/16 | 9/19 | 17/21 |
CNV detected in cell lines AB22 | Epithelial MM | Biphasic MM | Sarcomatoid MM |
del(1)(pter32) | + | + | (+) |
amp(1)(p32p10) | + | − | + |
del(3)(p24p24) | + | − | (+) |
del(3)(p21.2p14.2) | ? | ? | (+) |
amp(3)(p14.2q21) | + | + | + |
del(3)(q26qter) | ? | ? | − |
del(4)(pterq21.1) | + | + | + |
amp(5)(p15.3p12) | + | − | + |
del(5)(q11qter) | ? | ? | (+) |
del(6)(q16q25) | + | + | + |
amp(7)(pterp22) | + | + | ? |
del(7)(p22qter) | − | − | + |
del(8)(p22p12) | + | + | + |
amp(8)(q22qter) | + | (+) | + |
del(9)(q21.2q22.3) | (+) | (+) | ? |
del(10)(pterq23.2) | + | + | + |
amp(11)(q11q13.3) | ? | − | ? |
del(12)(p12.1qter) | ? | − | + |
del(13)(q13q32) | + | + | + |
del(14)(q11qter) | + | + | + |
del(18)(pterqter) | + | (+) | + |
del(19)(pterp13.3) | ? | (+) | (+) |
amp(20)(pterqter) | + | − | (+) |
del(22)(q11.2q11.2) | + | + | + |
del(22)(q13.2qter) | + | + | + |
Sum for + | 17/20 | 11/22 | 15/23 |
Sum for (+) | 1/20 | 4/22 | 6/23 |
Sum for + and (+) | 18/20 | 15/22 | 21/23 |
CNV detected in cell lines AC29 | Epithelial MM | Biphasic MM | Sarcomatoid MM |
amp(1)(p31 q25) | − | − | (+) |
amp(2)(p23p11.2) | − | − | + |
amp(2)(q33qter) | + | − | + |
amp(3)(pterq24.3) | + | − | − |
amp(3)(p14.1p13) | + | + | ? |
amp(3)(q25q26.2) | (+) | (+) | + |
amp(5)(p15.2p13.1) | + | − | + |
del(5)(q21q32) | ? | ? | (+) |
amp(5)(q33qter) | ? | + | − |
del(6)(q15q16.1) | + | + | + |
del(7)(p21p15.1) | + | + | ? |
amp(7)(p13p11.1) | − | − | − |
del(7)(q21.3q36) | + | + | + |
amp(8)(p12p11.1) | + | − | − |
amp(8)(q22.2qter) | + | (+) | + |
del(9)(pterq33) | + | + | + |
del(13)(q13q14.1) | + | + | + |
del(15)(q13q21.1) | − | − | (+) |
del(17)(pterp12) | + | + | (+) |
del(17)(q11q23) | ? | − | − |
amp(17)(q24qter) | + | − | (+) |
amp(19)(p13.2p13.1) | ? | − | − |
amp(20)(q13.2qter) | + | − | + |
del(X)(p22p11.2) | (+) | − | − |
Sum for + | 14/20 | 8/23 | 10/22 |
Sum for (+) | 1/20 | 2/23 | 5/22 |
Sum for + and (+) | 15/20 | 10/23 | 15/22 |