Table 1 The previously reported AML cases with t(8;16)(p11.2;p13.3) and 1q duplication

Case 2

F

28

M5

46,XX,t(8;16)(p11.2;p13.3), add(14)(p11.2)[11]/46,XX[9]

1q32.1q44

CR after induction

Relapsed 3 months later

Alive

Case 3

F

69

M5

46,XX,t(8;16)(p11.2;p13.3)[2]/46,idem,add(3)(q?27)[18]

1q32.1q44

spontaneous regression

Died

Haferlach et al.

F

39

M5a

45,XX,t(8;16)(p11;p13),der(10;13)(q10;q10)[10]/46,XX,der(7)t(1;7)(q21;q35),t(8;16)(p11;p13)[2]/46,XX[1]

1q21

NA

NA

Diab et al.

M

14.5

M4

46,XY,+1,del(1)(p22),t(8;16)(p11;p13),-10,der(14)t(10;14)(q11.2;p11.2)[8]/47,XY,del(1)(q11),+der(1)t(1;8)(p11;q11.2)x2,+i(5)(p10),-8,-10,der(14)t(10;14)(q11.2;p11.2),der(16)t(8;16)

Partial 1q gain

CR for 10.5

Dead

Diab et al.

F

14.2

M4/5

5,XX,t(8;16)(p11;p13),-18,der(21)t(1;21)(q12;p13)[4]/46,XX[16]

1q12

CR for 5

Alive

Diab et al.

F

1.2

M4

46,XX,t(8;16)(p11;p13)[3]/46,idem,der(10)t(1;10)(q11;p11)[5]/46,idem,add(7)(p21),der(10)t(1;10)(q11;p11)[2]/46,idem,add(7)(p21)[2]/46,XX[2}

1q11

CR for 0.6

Died

Diab et al.

F

14.1

M4

46,XY,t(8;16)(p11;p13),der(14)t(1;14)(q31;p11)[20]*

1q31

CR for 11.5

Alive

Diab et al.

F

7.3

M5

46,X,der(X)t(X;1)(q26;q23),t(8;16)(p11;p13),der(11)t(11;11)(p11;q13)

1q23

NA

NA

Xie et al.

M

28

M4

46,XY,der(3)t(3;8)(q27,q13),del(6)(p22),t(8;16)(p11.2;p13.3),del(10)(q21q25),add(13)(p11.2),del(16)(p12),del(20)(p11.2),del(20)(q11.2q13.3)[4]/46,idem,del(1)(p35p36.3),del(15)(q23),add(19)(p13.1)[2]/46,XY,t(8;16)(q27;q13),del(12)(q21q24.1),del(13)(q21q31),-16,der(19)t(1;19)(q32;p13.3),+mar[3]/46,XY,del(6)(p22),t(8;16)(p11.2;p13.3)[cp2]/46,XY[9]

1q32

CR for 7 months

Dead

Brown et al.

M

71

M4

47,X,der(Y)t(Y;1)(q12;q21), +6,t(8;16) (p11;p13)[6]/47,idem,del(13)(q3q3) [checked with CAD data]

1q21

No CR

Died 1 month after treatment

Brown et al.

F

1.2

M4

46,XX,t(8;16)(p11;p13)[3]/46,idem,der(10)t(1;10)(q11;p11)[5]/46,idem,add(7)(p21),der(10)t(1;10) (q11;p11) [2]/46,idem,add(7)(p21) [2]/46,XX [2]

1q11

Early remission after course 1. Relapsed at 5 months and 7 months after diagnosis

Died