Table 4 Detection rate of clinically significant chromosomal aberrations in fetuses with various CFMs
From: Clinical application of chromosomal microarray analysis for fetuses with craniofacial malformations
Malformation | Simple CFMs | Complex CFMs (n/N) | Referred cases (n/N, %) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Cranial malformation (n/N) | Orofacial cleft (n/N) | Nasal deformity (n/N) | Ocular malformation (n/N) | Ear abnormality (n/N) | Macroglossia (n/N) | Micrognathia (n/N) | |||
Isolated CFMs | 1/9 | 5/25 | 0/5 | 0/0 | 0/2 | 0/0 | 1/1 | 0/5 | 7/47, 14.9% |
Non-isolated CFMs | 10/32 | 8/19 | 0/0 | 1/6 | 1/1 | 0/1 | 0/0 | 6/12 | 26/71, 36.6% |
Total | 11/41 | 13/44 | 0/5 | 1/6 | 1/3 | 0/1 | 1/1 | 6/17 | 33/118, 28.0% |