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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: 13q deletion syndrome resulting from balanced chromosomal rearrangement in father: the significance of parental karyotyping

Fig. 1

Balanced complex chromosomal rearrangement between chromosome 12 and 13 detected by FISH analysis on metaphase chromosomes of the patient’s father. a FISH with whole chromosome paint (wcp) probes for chromosome 12 (red) and 13 (green) reveals a signal for the probe wcp 13 (green) on one chromosome 12. Thus, the derivative chromosome 12 has an insertion of material from chromosome 13 (der(12)ins(12;13)). b The inserted Region contains the RB1 gene. The probe for RB1 (red) provides a signal on the derivative chromosome 12 and a signal on one of the chromosomes 13 (wcp 13, green) – no signal for RB1 on del(13)

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Molecular Cytogenetics

ISSN: 1755-8166