An acquired stable variant of a dicentric dic(9;20) and complex karyotype in a Syrian childhood B-acute lymphoblastic leukemia case

Table 1 Summary of CNAs detected by aCGH

Chr.	Start –End band	Genomic position: start- end GRCh37/hg19	Variant type	Size (Mb)	COSMIC census cancer gene(s) within the region
7	p22.3p15.2	109,626-26,260,755	loss	26.1	*CARD11, PMS2, RAC1, MACC1, HNRNPA2B1*
7	p14.2p11.2	35,292,065-56,174,888	loss	20.8	*SFRP4, IKZF1, EGFR*
8	p23.3p11.1	176,452-43,399,198	gain	43.2	*ARHGEF10, PCM1, LEPROTL1, WRN, NRG1, NSD3, FGFR1, ANK1, KAT6A, IKBKB, HOOK3*
8	q11.1q24.3	46,939,154-146,294,098	gain	99.3	*TCEA1, PLAG1, CHCHD7, PREX2, NCOA2, HEY1, CNBD1, NBN, RUNX1T1, CDH17, COX6C, PABPC1, UBR5, EIF3E, RSPO2, CSMD3, RAD21, EXT1, MYC, NDRG1, FAM135B, RECQL4*
9	p24.3p13.2	207,437-37,270,400	loss	37.1	*JAK2, CD274, PDCD1LG2, PTPRD, NFIB, PSIP1, MLLT3, CDKN2A, FANCG, PAX5*
13	q12.3q24	32,035,219-115,059,020	loss	83.0	*BRCA2, NBEA, LHFPL6, FOXO1, LCP1, RB1, CYSLTR2, GPC5, SOX21, ERCC5,*
20	p13p11.1	60,747-25,713,574	gain	25.6	*SIRPA, CRNKL1,*
	q11.2	29,467,937-29,948,374	gain	0.5	n.a.
	q13.13	46,828,431-48,880,347	gain	2.05	n.a.

ISSN: 1755-8166