Skip to main content
Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Identification of a novel deletion mutation in DPY19L2 from an infertile patient with globozoospermia: a case report

Fig. 1

Consanguineous family analysis and phenotypes of patients with globozoospermia. a. Consanguineous pedigree of the proband family with complete deletion ofDPY19L2. The patient (II:1) was suffering from globozoospermia had homozygous deletion of exons 1, 11 and 22 of DPY19L2. And heterozygous deletion in exons 1, 11, 22 of DPY19L2 in mother of proband (I:2), while no mutation was found in exons 1, 11 and 22 of DPY19L2 of his father (I:1). b. Papanicolaou staining of sperm cells from normal control and the proband globozoospermia. Black arrows indicate spermatozoa from globozoospermia. Scale bar: 20 μm. c. Ultrastructure of the Sperm from normal control and patient with complete loss of DPY19L2 showing that the DPY19L2-null spermatozoa had round sperm head. The black arrow indicates the head of normal control sperm and the head of DPY19L2 completely missing sperm.

Back to article page

Molecular Cytogenetics

ISSN: 1755-8166