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Table 5 Frequency of alterations according to cytogenetic subgroups

From: Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis

 

DMBT1 deletion

KIAA0125 amplification

PRDM16 deletion

Present

Ausent

Present

Absent

Present

Absent

BCR-ABL1

9

0

9

0

1

8

Absence

53

22

41

34

41

34

p-value

0.1036

0.0032*

0.0294*

ETV6-RUNX1

7

0

7

0

0

7

Absence

55

22

43

34

42

35

p-value

0.1817

0.0381*

0.0119*

MLL-AF4

5

0

4

1

1

4

Absence

57

22

46

33

41

38

p-value

0.3195

0.6438

0.3597

TCF3-PBX1

14

1

14

1

1

14

Absence

48

21

36

33

41

28

p-value

0.0625

0.00031*

0.0003*

SIL-TAL1

3

0

3

0

  

Absence

59

22

47

34

0

3

p-value

0.5634

0.2685

42

39

     

0.2410

CT+

38

1

37

2

3

36

CT-

24

21

13

32

39

6

p-value

p < 0.001*

p < 0.001*

p < 0.001*

  1. CT+ chromosome translocation positive; CT chromosome translocation negative. *Significant difference between groups with and without aberrations, p ≤ 0.05, Fisher’s exact test
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Molecular Cytogenetics

ISSN: 1755-8166