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Table 5 Frequency of alterations according to cytogenetic subgroups

From: Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis

  DMBT1 deletion KIAA0125 amplification PRDM16 deletion
Present Ausent Present Absent Present Absent
BCR-ABL1 9 0 9 0 1 8
Absence 53 22 41 34 41 34
p-value 0.1036 0.0032* 0.0294*
ETV6-RUNX1 7 0 7 0 0 7
Absence 55 22 43 34 42 35
p-value 0.1817 0.0381* 0.0119*
MLL-AF4 5 0 4 1 1 4
Absence 57 22 46 33 41 38
p-value 0.3195 0.6438 0.3597
TCF3-PBX1 14 1 14 1 1 14
Absence 48 21 36 33 41 28
p-value 0.0625 0.00031* 0.0003*
SIL-TAL1 3 0 3 0   
Absence 59 22 47 34 0 3
p-value 0.5634 0.2685 42 39
      0.2410
CT+ 38 1 37 2 3 36
CT- 24 21 13 32 39 6
p-value p < 0.001* p < 0.001* p < 0.001*
  1. CT+ chromosome translocation positive; CT chromosome translocation negative. *Significant difference between groups with and without aberrations, p ≤ 0.05, Fisher’s exact test