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Table 4 Frequency of alterations according to characteristics of patients

From: Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis

  DMBT1 deletion KIAA0125 amplification PRDM16 deletion
Present Ausent Present Absent Present Absent
NCI-HR 16 14 19 11 41 13
NCI-SR 46 8 31 23 1 29
p-value 0.0036* 0.6483 p < 0.001*
≤1 years 5 2 4 3 3 4
> 1 to ≤10 years 44 10 34 20 26 28
> 10 years 13 10 12 11 13 10
p-value 11 0.6131 0.9994 1
p-value 22 0.6693 1 0.6746
p-value 33 0.0433* 0.4497 0.6200
WBC > 50 16 5 16 5 8 13
WBC ≤ 50 46 17 34 29 34 29
p-value 1 0.0802 0.4568
Leucopenia 5 0 5 0 0 5
Leucocytosis 54 18 40 32 37 35
p-value 0.3336 0.0720 0.0554
Male 38 11 31 18 21 28
Female 24 11 19 16 21 14
p-value 0.4515 0.5002 0.1839
  1. NCI-HR NCI-High risk; NCI-SR NCI Standard risk; WBC White blood count. 1 ≤ 1 years versus > 1 to ≤10 years; 2 ≤ 1 years versus > 10 years; 3 > 1 to ≤10 years versus > 10 years. *Significant difference between groups with and without aberrations, p ≤ 0.05, Fisher’s exact test