Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis

Table 3 The most frequent copy number variations found in pediatric ALL by aCGH

Frequency % (n = 16)	Chromosome	Reference region	Variant type	Genes involved
94	14	q32.33	Amp	KIAA0125^a
75	14	q11.22	Del	Several genes
62.5	7	7p12.2	Del	IKZF1
56.25	9	p21.3	Del	CDKN2A/B,MTAP
56.25	10	q26.13	Amp	DMBT1^a
56.25	22	q11.22	Amp	MIR650, IGLL5
50	15	q11.1	Del	HERC2P3
50	1	p36.32	Amp	PRDM16^a
50	19	q13.32	Amp	KLC3, ERCC2
37.5	4	q13.2-q13.3	Del	UGT2B4
31.25	12	q21.33-q22	Del	BTG1
25	13	q14.2	Del	RB1
19	7	p14.1	Del	TRGC2, TARP
19	11	q23.3	Del	KMT2A
19	12	12p13	Del	ETV6
12.5	7	p21.3-p15.2	Del	Several genes
12.5	3	q29	Del	DLG1
6.25	21	iAMP21	Amp	RUNX1

^aAlterations have never been described in literature for ALL. Amp amplification. Del deletion

ISSN: 1755-8166