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Table 3 The most frequent copy number variations found in pediatric ALL by aCGH

From: Identifying novel genetic alterations in pediatric acute lymphoblastic leukemia based on copy number analysis

Frequency % (n = 16) Chromosome Reference region Variant type Genes involved
94 14 q32.33 Amp KIAA0125a
75 14 q11.22 Del Several genes
62.5 7 7p12.2 Del IKZF1
56.25 9 p21.3 Del CDKN2A/B,MTAP
56.25 10 q26.13 Amp DMBT1a
56.25 22 q11.22 Amp MIR650, IGLL5
50 15 q11.1 Del HERC2P3
50 1 p36.32 Amp PRDM16a
50 19 q13.32 Amp KLC3, ERCC2
37.5 4 q13.2-q13.3 Del UGT2B4
31.25 12 q21.33-q22 Del BTG1
25 13 q14.2 Del RB1
19 7 p14.1 Del TRGC2, TARP
19 11 q23.3 Del KMT2A
19 12 12p13 Del ETV6
12.5 7 p21.3-p15.2 Del Several genes
12.5 3 q29 Del DLG1
6.25 21 iAMP21 Amp RUNX1
  1. aAlterations have never been described in literature for ALL. Amp amplification. Del deletion