Fig. 2

The karytyping and FISH result at initial diagnosis. FIGURE 2 (a): the karyotyping of 46,XY,der(15)t(15;17)(q22;q21),ider(17)(q10)t(15;17)(q22;q21). The arrows indicate abnormal chromosomes. FIGURE 2 (b): the karyotyping of 46,XY,t(15;17)(q22;q21). FIGURE 2 (c): FISH study using a PML-RARA dual-color, dual-fusion translocation probe. The metaphase cell showing three yellow PML-RARA fusion signals, one red signal (PML), and one green signal (RARA), consistent with the karyotype of ider(17)(q10)t(15;17)(q22;q21). FIGURE 2 (d): FISH study using a RARA dual color break apart rearrangement probe. The metaphase cell showing two red signals (5’RARA), one yellow fusion signal (RARA), and one green signal (3’RARA), consistent with the karyotype of ider(17)(q10)t(15;17)(q22;q21)