Fig. 1

The schematic presentation of the ultrasound findings of isolated 5p deletion cases in prenatal diagnosis, detailed size and location with known coordinates of the deletion in the literature and our cases. Black bars: Critical regions proposed for specific phenotypic features of 5p-. Gray bars: The deletion of previously reported 5p- cases with detailed breakpoint. Red bars: our six pure 5p- cases. EF: epicanthal folds, GD: growth deficiency, FD: facial dysmorphology, SD: speech delay, ID: intellectual disability, CHD: congenital heart disease, RA: renal anomalies, BM: brain malformations, VM: ventriculomegaly, ISS: increased subarachnoid space, VH: vermis hypoplasia, SUA: single umbilical artery, CSPD: cavum septum pellucidum dilation, CH: cerebellar hypoplasia, DCV: dysgenesis of the cerebellar vermis, CPC: Choroid plexus cyst, Iβ-HCG: increased β-HCG, CML: cystic adenomatoid malformation of the lung, INF: increased NF