Table 1 Chromosomal location, occurrence of breakpoint events (BP), odds ratio, located genes and association to fragile sites of the top-15 breakpoint regions. Genes that are associated with cancer in literature are marked with an asterisk
From: Genome reorganization in different cancer types: detection of cancer specific breakpoint regions
Chr | Start | End | Cytoband | BP in NMCE (20) | BP in Tumors (111) | Odds Ratio | BP in CCLE (917) | Genes | Fragile Sites |
|---|---|---|---|---|---|---|---|---|---|
1 | 118000001 | 118100001 | 1p12 | 0 | 23 | 10,68 | 4 | MAN1A2 | – |
2 | 4900001 | 5000001 | 2p25.2 | 0 | 23 | 10,68 | 26 | – | FRA2M |
4 | 88700001 | 88800001 | 4q22.1 | 0 | 24 | 11,26 | 2 | IBSP*, MPEP* | FRA4F |
5 | 45900001 | 46000001 | 5p12 | 0 | 24 | 11,26 | 1 | – | – |
5 | 46300001 | 46400001 | 5p11 | 0 | 26 | 12,47 | 81 | – | FRA5I |
7 | 11700001 | 11800001 | 7p21.3 | 0 | 24 | 11,26 | 5 | THSD7A* | FRA7L |
7 | 37600001 | 37700001 | 7p14.1 | 0 | 23 | 10,68 | 0 | NECAP1P1 | – |
7 | 103400001 | 103500001 | 7q22.1 | 1 | 23 | 4,97 | 1 | RELN* | FRA7F |
8 | 43400001 | 43500001 | 8p11.1 | 0 | 25 | 11,86 | 2 | – | FRA8I |
8 | 43700001 | 43800001 | 8p11.1 | 0 | 32 | 16,46 | 48 | – | FRA8I |
8 | 47300001 | 47400001 | 8q11.1 | 0 | 23 | 10,68 | 1 | – | FRA8I |
9 | 141000001 | 141100001 | 9q34.3 | 1 | 48 | 14,48 | 321 | CACNA1B* | FRA9N |
13 | 35900001 | 36000001 | 13q13.3 | 0 | 23 | 10,68 | 1 | NBEA* | – |
13 | 115100001 | 115106996 | 13q34 | 3 | 40 | 3,19 | 210 | – | FRA13I |
14 | 20400001 | 20500001 | 14q11.2 | 3 | 36 | 2,72 | 61 | OR4K1, OR4K5, OR4K14, OR4K15 | FRA14D |