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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

Fig. 2

Mitotic and chromosome replicative defects that can lead to CIN. Common defects in mitosis leading to CIN include cohesion defects, spindle assembly checkpoint dysfunction, supernumerary centrosomes and cytokinesis failure. Problems upstream of mitosis, during DNA replication and repair can include telomere dysfunction, leading to breakage-fusion-bridge (BFB) cycles, and replication stress

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