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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Molecular cytogenetic identification of small supernumerary marker chromosomes using chromosome microarray analysis

Fig. 2

Cytogenetic and molecular results of case P11. The marker is highlighted by a green arrow in a, d and e. a In 26 out of the 50 studied cells, G-banding revealed a karyotype 46,X,+mar. b In the other 24 cells, G banding revealed a karyotype 45,X. c The sSMC of case P11 characterized after SNP array covering 62 Mb [arr[GRCh37]Xp22.33q11.1(168,551_62,006,469) × 1] in chromosome X and 68 Mb [arr[GRCh37]Xq21.31q28(87,685,781_155,233,098) × 1] in chromosome X. d and e FISH using DXZ1 and D18Z1 probes for X and 18 chromosomes centromeres (green and turquoise signals, respectively). Confirmatory metaphase FISH results of this sSMC using the DXZ1 probe specific for X centromeric probe (CEP) revealed that 57% of the cells had two distinct signals

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