Analytical validation and chromosomal distribution of regions of homozygosity by oligonucleotide array comparative genomic hybridization from normal prenatal and postnatal case series

Table 1 Chromosomal distribution of ROH

Chromosome	Chromosome size (bp)	% of genome	Observed ROH size (Mb)	Expected ROH size (Mb)	Observed ROH No.	Expected ROH No.
1	247,199,719	8	339.2	258.2	68	96
2	242,751,149	7.9	601.4	413.1	132	94
3	199,446,827	6.5	230.0	407.9	52	78
4	191,263,063	6.2	334.9	335.6	73	74
5	180,837,866	5.9	288.0	320.1	73	71
6	170,896,993	5.5	420.3	304.6	98	66
7	158,821,424	5.2	159.1	284.0	40	62
8	146,274,826	4.7	567.8	268.5	150	56
9	140,442,298	4.6	110.7	242.7	40	55
10	135,374,737	4.4	267.3	237.5	85	53
11	134,452,384	4.4	245.8	227.2	71	53
12	132,289,534	4.3	302.5	227.2	76	51
13	114,127,980	3.7	180.7	222.0	43	44
14	106,360,585	3.5	112.8	191.0	27	42
15	100,338,915	3.3	26.2	180.7	5	39
16	88,822,254	2.9	23.6	170.4	8	35
17	78,654,742	2.6	128.9	149.7	21	31
18	76,117,153	2.5	231.6	134.2	59	30
19	63,806,651	2.1	32.0	129.1	5	25
20	62,435,965	2	76.8	108.4	18	24
21	46,944,323	1.5	43.8	103.3	5	18
22	49,528,953	1.6	31.6	77.4	5	19
X	154,913,754	5	408.4	82.6	42	60
Total	3,079,843,747		5163.3		1196

ISSN: 1755-8166