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Fig. 3 | Molecular Cytogenetics

Fig. 3

From: The rare mutation in the endosome-associated recycling protein gene VPS50 is associated with human neural tube defects

Fig. 3

Co-Immunoprecipitation illustrated the effect of novel mutations on the physical interaction of VPS50 with VPS53. HEK293t cells were co-transfected into 4μg VPS50 plasmid constructs in pairwise combinations with 4μg VPS53 cDNA. HA immunoprecipitation, blotting with anti-Flag confirmed physical interaction between WT VPS50 and VPS53. This interaction was decreased in the p. Gly169Val mutation

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Molecular Cytogenetics

ISSN: 1755-8166