Fig. 3From: Chromoanagenesis: cataclysms behind complex chromosomal rearrangementsThe concept of chromoplexy: a series of chained, complex inter- and intra-chromosome translocations, involving up to eight chromosomes with frequent deletions at their breakpoints and presumably occurring simultaneously. These serial rearrangements occur in the majority of prostate cancers. Non-homologous end-joining (NHEJ) is the predominant mechanism for reassembling then chromosomal fragmentsBack to article page