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Fig. 3 | Molecular Cytogenetics

Fig. 3

From: Chromoanagenesis: cataclysms behind complex chromosomal rearrangements

Fig. 3

The concept of chromoplexy: a series of chained, complex inter- and intra-chromosome translocations, involving up to eight chromosomes with frequent deletions at their breakpoints and presumably occurring simultaneously. These serial rearrangements occur in the majority of prostate cancers. Non-homologous end-joining (NHEJ) is the predominant mechanism for reassembling then chromosomal fragments

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