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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm

Fig. 1

a Karyogram showing translocation t(2;5)(p21;q33). b FISH analysis with a PDGFRB break-apart probe on interphase nuclei showing one normal intact fusion signal and one split signal (one red, one green) confirming PDGFRB gene rearrangement. c Metaphase FISH showing RP11-5644H16 to be split with signal on both the derivative 2 and the derivative 5, and RP11-378O10 translocated to the derivative chromosome 5. d Map of BAC probes relative to SPTBN1 gene. Direction of SPTBN1 transcription is towards the centromere on chromosome 2

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