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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: An uncommon t(9;11)(p24;q22) with monoallelic loss of ATM and KMT2A genes in a child with myelodysplastic syndrome/acute myeloid leukemia who evolved from Fanconi anemia

Fig. 1

a G-banded showing the der(9)t(9,11)(p24;q?22). The black arrows point the gain of chromosome material on 9p and the loss on 11q; b FISH analysis using LSI p16 probe [LSI p16 (9p21), red signal/CEP 9 (9p11-q11), green signal, Dual Color Probe, Vysis] and inverted DAPI, showing that CDKN2A gene was normal in a metaphase. The black arrows shows both CDKN2A normal signals; c FISH analysis using LSI KMT2A Dual Color break apart rearrangement probe Vysis, showing the monoallellic loss of the KMT2A gene with the loss of one signal in interphase nuclei (white arrows) and in metaphase using inverted DAPI (black arrow). d FISH using LSI ATM (11q22) spectrum orange probe, Vysis showing the monoallellic loss of ATM with the loss of one signal in interphase nuclei (white arrows) and in metaphase using inverted DAPI (black arrow)

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