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Table 3 Re-defined degree of consanguinity

From: Copy number variation and regions of homozygosity analysis in patients with MÜLLERIAN aplasia

 

Before Analysis

After Analysis

Patient

Parental Consanguinity (based on patient’s interview)

% Autosomal ROH

Parental Consanguinity Degree

1

No Info

3.7%

Fourth degree

2

No Info

2.9%

Fourth degree

3

First Cousins

10.3%

Second degree

4

First Cousins

10.7%

Second degree

5

First Cousins

11.4%

Second degree

6

No Info

4.0%

Fourth degree

7

No Info

6.86%

Third degree

8

No Info

5.8%

Third degree

9

No Info

9.9%

Second degree

10

No Info

4.4%

Third or fourth degree

11

No Info

3.7%

Fourth degree

12

No Info

13.1%

Second degree

13

First Cousins

18.3%

Second degree

14

First Cousins

8.8%

Second degree

15

First Cousins

14.7%

Second degree

16

First Cousins

20%

First or second degree

17

No Info

6.4%

Third Degree

18

First Cousins

23.5%

First degree

19

No Info

20.9%

Second degree

Consanguinity Degree

Theoretic Percentage

Percentage of Homozygosity (Confidence Interval)

First or closer

> 25%

> 28.7%

First

25%

21.3–28.7%

First or second

 

15.3–21.3%

Second

12.5%

9.7–15.3%

Second or third

 

8.3–9.7%

Third

6.25%

4.6–8.3%

Third or fourth

 

4.2–4.6%

Fourth

3.125%

2.6–4.2%

Fourth or fifth

 

1.6–2.6%

Fifth

1.5625%

0.5–1.6%