From: Copy number variation and regions of homozygosity analysis in patients with MÜLLERIAN aplasia
Before Analysis | After Analysis | ||
---|---|---|---|
Patient | Parental Consanguinity (based on patient’s interview) | % Autosomal ROH | Parental Consanguinity Degree |
1 | No Info | 3.7% | Fourth degree |
2 | No Info | 2.9% | Fourth degree |
3 | First Cousins | 10.3% | Second degree |
4 | First Cousins | 10.7% | Second degree |
5 | First Cousins | 11.4% | Second degree |
6 | No Info | 4.0% | Fourth degree |
7 | No Info | 6.86% | Third degree |
8 | No Info | 5.8% | Third degree |
9 | No Info | 9.9% | Second degree |
10 | No Info | 4.4% | Third or fourth degree |
11 | No Info | 3.7% | Fourth degree |
12 | No Info | 13.1% | Second degree |
13 | First Cousins | 18.3% | Second degree |
14 | First Cousins | 8.8% | Second degree |
15 | First Cousins | 14.7% | Second degree |
16 | First Cousins | 20% | First or second degree |
17 | No Info | 6.4% | Third Degree |
18 | First Cousins | 23.5% | First degree |
19 | No Info | 20.9% | Second degree |
Consanguinity Degree | Theoretic Percentage | Percentage of Homozygosity (Confidence Interval) | |
First or closer | > 25% | > 28.7% | |
First | 25% | 21.3–28.7% | |
First or second | 15.3–21.3% | ||
Second | 12.5% | 9.7–15.3% | |
Second or third | 8.3–9.7% | ||
Third | 6.25% | 4.6–8.3% | |
Third or fourth | 4.2–4.6% | ||
Fourth | 3.125% | 2.6–4.2% | |
Fourth or fifth | 1.6–2.6% | ||
Fifth | 1.5625% | 0.5–1.6% |