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Table 3 Highly deregulated genes in the CLL cells of the translocation patient versus normal B-cells (FC > 10, FDR p < 0.01)

From: Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3)

Gene Symbol Fold Change FDR p-value Deregulation in CLL Reference
INSM1 209.42 0.000137   
ASCL1 202.32 0.000029   
ABCA9 118.18 0.000114 overexpressed [17] [19] [20]
PAH 84.87 0.000166   
MRO 82.52 0.000408   
GABRB2 42.47 0.000495 overexpressed [21]
PAX9 38.71 0.000800   
RNF150 27.45 0.000748   
FHDC1 25.51 0.000537 overexpressed [17] [19] [20]
KCNJ11 20.52 0.000458 overexpressed [19] [20]
KSR2 20.37 0.000748 overexpressed [17] [20]
FGF2 18.37 0.000748 overexpressed [22]
GLDN 18.02 0.000881   
EDNRB 12.07 0.000495   
APP −21.43 0.000489 underexpressed [21]
RGS2 −24.38 0.000902 underexpressed [17] [19]
EBF1 −61.42 0.000976 underexpressed [17] [19]
RGS1 −98.36 0.000970 underexpressed [17] [23]
  1. Information about gene deregulation in CLL and relevant references are shown