Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3)

Table 3 Highly deregulated genes in the CLL cells of the translocation patient versus normal B-cells (FC > 10, FDR p < 0.01)

Gene Symbol	Fold Change	FDR p-value	Deregulation in CLL	Reference
INSM1	209.42	0.000137
ASCL1	202.32	0.000029
ABCA9	118.18	0.000114	overexpressed	[17] [19] [20]
PAH	84.87	0.000166
MRO	82.52	0.000408
GABRB2	42.47	0.000495	overexpressed	[21]
PAX9	38.71	0.000800
RNF150	27.45	0.000748
FHDC1	25.51	0.000537	overexpressed	[17] [19] [20]
KCNJ11	20.52	0.000458	overexpressed	[19] [20]
KSR2	20.37	0.000748	overexpressed	[17] [20]
FGF2	18.37	0.000748	overexpressed	[22]
GLDN	18.02	0.000881
EDNRB	12.07	0.000495
APP	−21.43	0.000489	underexpressed	[21]
RGS2	−24.38	0.000902	underexpressed	[17] [19]
EBF1	−61.42	0.000976	underexpressed	[17] [19]
RGS1	−98.36	0.000970	underexpressed	[17] [23]

ISSN: 1755-8166